COGIMAX ®

Cogimax is supplied in bottles of 180 tablets of 50mg silica and 120 tablets of 150mg silica.

A specially formulated silica-mineral complex containing 50mg & 150mg of measured silica per tablet

I. BACKGROUND INFORMATION

The element silicon does not exist in nature in its pure state, but combines with 2 molecules of water to form silica. Next to oxygen, silicon is the most abundant element in the earth's crust, with 60% of rocks containing silica. The erosion of rocks spreads silica and silica-mineral complexes into the soil, streams and ground water. When silica combines with 2 molecules of water, it becomes silicic acid, a weak acid which exists in its free state below pH9.0. Silicic acid and mineral silicates are the active forms of silica and silicon in both plants and animals. In plants, silicic acid is absorbed from the moist soil and after further processing, performs important functions in the plants, including protection against bacteria, insects and snails. Silicic acid protects the plant from toxicity of excess metals in the soil, such as iron and manganese.

Herbivorous animals and men obtain silicic acid from plants and from fresh unprocessed water. Addition of aluminum to water during water treatment prior to consumption by animals and men, removes silicic acid from water by binding aluminum to silicic acid, making it unavailable for absorption by the intestinal tract. Processing of foodstuff from plants origin decreases markedly the amount of silica. For example, Barbados brown sugar contains 750 parts per million (PPM) silicon, compared to 2 PPM in refined sugar.

Some 30 years ago, the essentiality of the element silicon, in the form of bioactive and bioavailable mineral silicates was demonstrated in higher animals, based on research performed by Edith M. Carlisle and Klaus Schwartz from U.C.L.A. Bioactive silicates participated in the normal metabolism of higher animals, and are essential for normal growth, bone formation, and production of connective tissue. The highest silicon concentrations occur in connective tissues, such as the aorta, the trachea, the tendons and also the skin. Aging causes a marked drop in silicon content of the aorta and the skin only, not in silicon contents of other tissues examined, In laboratory animals, silicates protect the aorta from atheromatous lesions induced by a high fat diet. In man, the silicon content of the aorta was highest in normal aortas, and decreased with increased atheromatous lesions of the aorta.

The protein collagen represents at least one third of the total protein content of the human body. Silicic acid and silicates increase the production of collagen by several mechanisms, one of which is the stimulation of an enzyme involved in the conversion of procollagen to collagen.

An association between silicon deficiency and Alzheimer disease (AD) was proposed by Carlisie in 1987. In AD patients, high brain aluminum levels in certain brain regions has been previously reported, Using rats as experimental animals, Carlisle demonstrated a protective role of silicates against brain toxicity of aluminum. She also observed that aluminum depletes brain silicon levels mainly in areas involved in AD.

AD occurs in 5% of individuals over 70 years old and is twice as common in women as in men.

Serum silicic acid is lower in post-menopausal women than pre-menopausal women. The effect of castration in laboratory animals on serum silicic acid showed that in female rats, castration decreases serum silicic acid by one half, whereas no effect was observed in male rats. This could explain the higher preponderance of AD in women than in men. The decrease incidence of AD in post-menopausal on estrogen therapy could be due to increased silicic acid and silicates in the brain. Carlisis proposed that silicon performs an essential role in brain metabolism; and that aluminum interferes with the action of silicon by lowering brain silicon levels.

So far, these findings have not been translated into practical recommendations for human health. The only balance study published on silicon showed that men on 2 different diets, namely a low fiber and a high fiber diet, were all in negative balances after 26 days on those diets. Negative balance means they were losing bioactive silicon, that is silicic acid and silicates while on these diets The 24hr. Urine silicon excretion levels in human subjects ranged from 5 to 30 mg, equivalent roughly to 10 to 60 mg of bioavailable silica.

II. FORMULATION OF COGIMAX

Cogimax is a specially formulated silica-mineral complex containing 50 mg of measured silica per tablet. The silica-mineral complex is coated with a non-ionic surfactant in order to minimize interaction between the silica-mineral complex and compounds in the intestinal tract capable of interfering with the absorption of silicic acid and mineral silicates, Citric acid is added to increase the intestinal release of silicic acid and silicates from the silica-mineral complex.

III. SUGGESTED USE

The recommended daily amount is one tablet with a glass of water in the morning. However, more than one tablet may be ingested upon recommendation of a health care practitioner. For best results, ingest Cogimax tablets with a glass of water on an empty stomach. Consume at least 2 quarts of water a day. Bioactive silicates increase the hydration of extracellular substances, and therefore adequate intake of water is required to replenish the extracellularinterstitial fluid.

Publications:

The Importance of BioAcitive Silicates in Human Health, The Original Internist. Spring 2005: pg 13-19

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For more information and to request a manuscript with references to original publications, Write to:

OPTIMOX CORPORATION

P.O. Box 3378 Torrance, CA 90510-3378

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